Mutation and Gene Disruption

Mutation and Gene Disruption

Analysis of phenotypic changes resulting from mutagenesis and gene disruption Mutation and gene disruption are powerful tools for investigating gene function and for identifying novel genes without prior knowledge of homology in other systems. Screening for phenotypes of interest leads to discovery of new genes, some of the mutations becoming models for human genetic diseases. […]

Proteomics

Proteomics

As a genome describes the genetic content of an organism, a proteome defines the protein complement of the genome. Proteomics includes the identification of proteins in biological tissues, the characterisation of their physicochemical properties (complete sequence, post-translational modifications), and the description of their behaviour (function, expression level). After processing and modifications, a single gene may […]

Structural Genomics

Structural Genomics

Structural genomics is the assignment of three-dimensional structures to proteomes and the investigation of their biological implications. Protein structure is an important indicator of function, particularly where the structure of a new protein is homologous to one already known. Two levels of assignment are employed in structural genomics, one being experimental large-scale determination of protein […]